AchooAllergy.com Blog

SLIT


Posted by R. Power on Saturday, October 18, 2014
Allerdent by Allovent ­ImmunotherapyWhile immunotherapy is the most effective method for allergy management, it's more difficult to make it as much of a habit as say, brushing your teeth.... until now? You soon may be able to do just that immunotherapy WHILE brushing your teeth! Allergy patients at Weill Cornell Medical College in New York City are currently brushing with Allerdent, a specially formulated immunotherapy toothpaste delevoped by Dr. William Reisacher and Allovate, LLC. Allovate, LLC. is a start up pharmaceutical company, specializing in innovative and improved approaches to allergy immunotherapy. Using Allerdent as their product platform this could be the next big thing to replace our traditional immunotherapy treatments that are currently in use.

Brushing Your Way to Allergy Relief"If you can contact those extracts with the lining of the mouth then you can desensitize patients to those allergens and essentially cure them of their allergies" explains Dr. Reisacher. Allerdent will be customized to each person's needs, containing the specific allergen(s) that the patient is allergic to. Dereck Lacarubba is a patient who currently participates in this Allerdent experiment, and is allergic to cats, dogs, tree pollen and dust. He claims that it works and tastes just like regular fluoride toothpaste. Further, he says it's been helping him with his environmental allergies day after day.

The current options for allergy immunotherapy (IT) are Subcutaneous Immunotherapy (SCIT), better known as allergy shots, or daily Sublingual Immunotherapy Treatment (SLIT), drops under the tongue. However, there are many obstacles that contribute to less than 5% of allergy rhinitis patients actually receiving either of these types of immunotherapy.

Allergy shots are costly, time consuming, weekly visits for three to five years (and we know how long doctor visits take), and the presence of needles is a problem some, both adults and children alike. SLIT drops are to be taken everyday, and placed under you tongue for two minutes. Like birth control or acid reflux medicine, you can't skip a day or else it will not be as effective as it should be. For many, this stringent routine is difficult to maintain. SLIT is also a method that is currently NOT endorsed by the FDA. That lack of endorsement adds some measure of skepticism to this method allergy immunotherapy.

One Habit, Two Positive Benefits?Allerdent is a very innovative yet simple idea, that takes your existing routine, brushing your teeth, and adds in the practice of receiving immunotherapy. This simple yet novel approach is what makes Allerdent so promising. I would love to kill two birds with one stone, keeping my oral hygiene up while having the ability to snuggle up to a cat without the tidal wave of congestion and itchy, watery eyes that currently accompanies it. I'm sure others are also excited to cross off biweekly doctor's visits from their agendas or cease taking medications that aren't currently FDA approved. Either way, novel approaches like this, regardless of outcome, present a new twist to traditional treatment and pavethe way for the better treatments of the future.

For more information about Allovate or Allerdent.

Author: R. Power

Posted by R. Power on Friday, April 18, 2014
Oralair - Oral SLIT Treatment for Grass Allergies Approved by FDACommon Allergic Grasses - Timothy, Orchard Grass, Sweet VernalThe US Food and Drug Administration (FDA) has given the thumbs up for Oralair (Stallergenes, Inc.) to be on the market as the US’s first sublingual immunotherapy (aka, SLIT) to treat allergies to multiple grass pollens. More importantly, this is the first SLIT treatment available as a pill. Traditional SLIT treatment involves a series of injections.

Treatment is suitable for the age range of 10-65 years, and to those who are diagnosed with grass pollen-induced allergic rhinitis (with or without conjunctivitis). Patients must have positive skin test or in vitro testing for any of the five grass species: sweet vernal, orchard, perennial rye, timothy and Kentucky blue grass (I thought this last one was a joke because I love blue grass music).

Last December the Allergenic Products Advisory Committee gave a unanimous vote to recommend Oralair as the first SLIT for the United States. Sublingual immunotherapy has been a common allergy medication throughout Europe and the rest of the world. Twenty years of research has shown SLIT to be safe and effective as an allergy medication. While in testing, the most common treatment emergent adverse events (TEATs) in adults and children were throat irritation and oral pruritus (itching).

My fingers are crossed for this treatment to be effective and to help secure a path into finding more natural treatments for allergies and other ailments.

Author: R. Power

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