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PureGuardian 4600 Ultrasonic Humidifier

  • Item #: GG011

PureGuardian 4600 Ultrasonic Humidifier

PureGuardian, one of the leaders in utilizing safe and natural technologies, has outdone themselves with the new, high capacity, H4600 Ultrasonic Humidifier. While it boasts the same great qualities as other PureGuardian humidifiers, this one stands apart from the crowd. Instead of a typical humidifier run time of 10-72 hours, the H4600 up to 144 hours depending on the settings and humidity in the room. At 2.4 gallons, the tank capacity for these units is double that of the previous models! The larger tank means fewer refills, and the array of features that come standard with digital Pure Guardian humidifiers makes the 4600 easy to use and operate. And best of all, it sits at a price that is below that of comparable models.


  • H4600 Controls: Digital display with push button controls
  • Warm or Cool Mist output (Warm mist will feel only slightly warmer near mist spout)
  • Silver Clean Technology helps to eliminate germs and bacteria on the tank
  • Tank Empty Light - front panel indicator will light up when water level is low
  • Auto Shut-Off when the tank is empty
  • Variable Control Speeds
  • Up to 144 hour run times on one tank fill (estimate based on low and cool mist settings)
  • 2.4 Gallon Tank Capacity
  • Soft Blue Night Light with on/off switch
  • Virtually Silent Operation
  • High output mist nozzle

Pure Guardian H4600 Room Humidifier Reviews

PureGuardian H4500 Ultrasonic Humidifier

As the largest of the PureGuardian home humidifiers, the H4500 retains all of the features you have come to expect from PureGuardian while dramatically increasing the run time between water refills. This new model holds nearly 2.5 gallons of water and can run for up to 120 hours before it needs to be refilled. With the H4500 in tow, I headed home to see how this model would perform over a weekend of constant use.

What I like about the PureGuardian H4500 Humidifier

You'll immediately notice the size of this unit when you open the box. While the shape and styling is in line with all of the PureGuardian humidifiers, this model has a noticeably wider base and much larger tank. The very practical upside to the much larger capacity of the H4500 is that the humidifier will run much longer than other Pure Guardian models and most comparable models. The product specifications say 120 hours without having to refill the unit. I ran this unit dead center on the humidity control knob.

With a full tank starting at 7 pm on a Friday, the unit ran until Monday night at 7 pm. So it worked 3 full days. When I was done, I measured out the remaining water. I had just under six cups (about a quart and a half of water). On my setting in my living room, I would probably really be stretching it to get a full 120 hours per tank. I estimate that under my conditions I would have to refill the H4500 at just before the 100 hour mark. To put this in perspective, I would have to the fill the tank about every 4 days with continuous use. Most of the other models we sell are dry before you hit the 48 hour mark.

Using this humidifier is very easy. You simply unscrew the bottom opening, fill, tighten the cap back on, and then place the tank back on the unit. The humidity level is set with the large dial in the center, and you can select either cool or warm mist with the main control knob. Other than this, you simply refill the unit when the indicator light tells you, or when you can visibly see the water level is low.

No maintenance is a very nice added benefit. With evaporative humidifiers, there is always an evaporator wick which needs to be replaced. Wicks can be a breeding ground for bacteria. The Pure Guardian H4500 requires no wicks or demineralization cartridges. Should you notice a mineral buildup, you can allow the unit to dry and remove it from the diaphragm with the supplied brush. Another solution is to use a mix of vinegar and water to wipe the water tank or inner system. Aside from this, there really is no maintenance for these home humidifiers.

As a cool mist ultrasonic humidifier, the H4500 is ideal. The output is excellent, and there is no worry of small children possibly getting burned. On the warm mist setting, you may be surprised. Unlike some models which actually boil the water, the warm mist is very safe even around small children. This is because the temperature never gets very hot. The upside is it eliminates any safety concern. The downside is, if you are looking for a unit that actually boils the water to a hot steam, the Germ Guardian H4500 is not what you are looking for.

For some the night light may be an added benefit. Personally, I prefer a room that is as near to completely dark as possible, but should you need a little light for in the middle of the night, the option is there.

Lastly, if you are looking for a quiet home humidifier, the H4500 is it. Even on the highest setting, it makes very little noise.

What I do not like about the PureGuardian H4500 Humidifier

This is, and likely will always be my complaint with most humidifiers, there simply is no easy way to move these things, especially once the tanks are full of water. Granted, you really shouldn't be moving your humidifier around, but handle and hand holds are deceptive on all humidifiers. They are almost exclusively for carrying the water tank, NOT the entire unit. Don't grab a handle or handhold thinking you are picking up the entire unit. This can be very messy.

These models both lack any sort of hygrometer or humidistat. For this model in particular, to monitor the humidity level, you would have to make an additional purchase. For many of us though, you will adjust the humidity until you are comfortable. In my case, I adjust the setting to the point where when I wake up in the morning, my throat is not sore. For something more accurate, you'll have to purchase a hygrometer.

Overall, the PureGuardian H4500 is very similar to its smaller Pure Guardian counterparts in performance and functionality. The main difference is the size of the tank and how long you can use the unit between refills. You can adjust to have the mist point in two different directions and maintenance is not an issue. The H4500 is very easy to use and will work well for most of the largest rooms in your home. If a humidity reading is not essential, this home humidifier is ideal for humidifying the largest rooms in your house without frequent refills or costly maintenance.

Product Questions

my model h4500 only puts out a small amount of vapor. is there a possible blockage internaly ,or could I use a diluted clr solution?
The "tear" light stays on flashing, will not restart.
Does the Germ Guardian H4500 Ultrasonic Humidifier produce the white dust that some others do? Thank you.

PureGuardian 4600 Ultrasonic Humidifier Additional Resources

Pure Guardian H4600 / H4500 User's Manual